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Biophysical and Structural Characterization of Biological Macromolecules

Our research group explores complex biological problems associated with signal transduction and neurodegenerative diseases, including Alzheimer’s disease, ALS, and Parkinson’s disease. We are especially interested in understanding the interplay between protein dynamics and function.


We characterize the structure-function interplay and conformational dynamics of biological macromolecules using a range of cutting-edge biophysical methods. Our primary research interests are:

Solution NMR spectroscopy.

Solution NMR elucidates the structures of biomolecules in their native environment. It is also unique in its ability to elucidate the range of motions that are exhibited by biomolecules. These motions provide vital information regarding ligand recognition, protein assembly, conformational dynamics, and other essential cellular processes.

Protein phase separation and amyloids.

Phase separation of proteins orchestrates a variety of cellular processes, and its dysregulation can lead to amyloid fibrils, which are often associated with proteinopathies. We want to understand the mechanistic underpinnings of these transitions. Additionally, we seek to understand the phenomenon of functional amyloids that perform essential physiological roles without succumbing to pathology.

Posttranslational modifications (PTMs).

PTMs are used to extend and diversify the signals encoded by a given protein. Some of the common PTMs include the introduction of a functional group (e.g., phosphorylation), covalent conjugation of peptides or proteins (e.g., ubiquitination), and proteolytic cleavage of the target protein. We are especially interested in proteolysis, tyrosine phosphorylation, and ubiquitination.


Dr. Lalit Deshmuckh

Lalit Deshmukh Assistant Professor
Department of Chemistry & Biochemistry


  • Bhargavi Ramaraju
    Post-doctoral fellow, 2018 - 2020 Linkedin
  • Ruben D. Elias
    PhD student, 2019 - 2023 Linkedin
  • Aman Shihora
    Undergraduate researcher, 2020 - 2023 Linkedin
  • John Brown
    Undergraduate researcher, 2021 - 2022 Linkedin
  • Chenrong Yu
    Master's student, 2021 - 2023 LinkedIn



Prior to UCSD - National Institutes of Health



Contact information

Department of Chemistry and
University of California San Diego
9500 Gilman Drive
La Jolla, CA 92093-0375
Office – NSB #3113
Lab – NSB #3108

Phone (office): (858)-246-3343
Phone (lab): (858)-246-3161